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Medication that inhibit CYP2D6 exercise, like paroxetine and quinidine, may possibly cause reduced clearance of oxycodone which could lead to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in an increase in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.Sufferers needs to be titrated to suffering ai